ABSTRACT
Obstructive sleep apnea [OSA] is partial or complete recurrent upper airway obstructions during sleep. Reduction in blood flow of the optic nerve head is an important causative factor in glaucoma. The objective of this study is to determine the prevalence of primary open angle glaucoma [POAG] in OSA patients. From September 2009 to January 2010 in this descriptive-analytic cross sectional study, 90 cases of patients with OSA referred to Yazd Shahid Sadoughi hospital were collected and studied by polysomnography, blood gas analysis and ocular examination including measurement of intra ocular pressure, gonioscopy, fondoscopy and automated perimetry. Statistical analysis was performed by SPSS software. Thirty-one patients had mild OSA, 30 patients had moderate OSA and 29 patients had severe OSA. The prevalence of POAG in this group of patients was 10% [95% CI: 4-16]. It is higher than the general population in the same age group [p=0.017]. There was no significant correlation between the presence of glaucoma and apnea hypopnea index [AHI], mean saturation arterial O[2] [MSaO[2]], body mass index [BMI], sex and age. A significant correlation between AHI with IOP and cup/disc ratio was not documented. According to our founding, the prevalence of POAG in OSA patients was higher than the general population in the same age group. Thus we recommend screening of glaucoma in OSA patients. This Study suggests that AHI, MSaO[2], BMI, sex or age are not important risk factors for glaucoma in OSA patients
ABSTRACT
This study determined the clinical effect of subconjunctival administration of bevacizumab in patients with primary and recurrent pterygium. The study was an off-label, single-dosing, interventional case series involving 22 patients with primary and recurrent pterygium. They received subconjunctival bevacizumab [0.2cc]. Pterygium vascularity and thickness was graded. The size of the pterygium [measured by surface area in cm[2]] was recorded from baseline to 12 weeks, after injection. Treatment-related complications and adverse events were reported. The main outcome of measurements was the change in size, vascularity, thickness, color intensity. There were 15 males [68.2%] and 7 females [31.8%] of 22 patients with a mean age of 45.5 years [SD 11.68 years]. One cases didn't cooperate, and excluded. There was a significant difference in the mean surface area of pterygium at different intervals [P < 0.05] and the size of pterygium was reduced. On comparison of the mean pterygium size, there was no significant difference between men and women [P >0.05]. There was a significant reduction in the mean pterygium size of patients younger than 45 years in comparison to those older than 45 years after three month [P =0.037], but after 6 months, this difference was not significant [P = 0.338]. Average changes in pterygium size for both eyes were not different. The reduction of color intensity in both eyes was significant [P =0.031]. Subconjuctival bevacizumab injection is useful in management of patients with primary and recurrent pterygium without significant local or systemic adverse effects
Subject(s)
Humans , Male , Female , Antibodies, Monoclonal, Humanized , ConjunctivaABSTRACT
AIM: To describe the involvement in relatives of kera-toconus (KCN) patients with corneal topography map. METHODS: A total of 300 eyes of 150 siblings of 75 KCN patients referred to corneal clinic were studied and experienced complete slit-lamp, refraction examinations and topographic cornea maps provided by videophoto-keratography. ANOVA, Fisher exact and Chi-square tests were performed to compare the results.RESULTS: From 150 siblings, 56% were female and 44% were male with average age of 21 (range of 15-39) years old. KCN and suspect KCN diagnosed in 12.3% and 6.6% respectively. The central keratometry (CK) was 46.50±4.51 dioptr(D) in KCN and 45.66±1.52 (D) in suspect KCN. Inferior-superior value (I-S) was 3.51±2.50(D) in KCN and 1.56±1.22 (D) in suspect KCN. In KCN condition the oval pattern was 67.6% (n=25) and round pattern detected was 32.4% (n=12). In suspect KCN these patterns detected were 90% and 10% respectively. Refractive errors in KCN were -7.50 to +1.25D(-1.25±1.83), in suspect KCN 0.45 to -4.2D(-0.68±0.76) and in healthy group 2.75 to -7.5D(-0.6±1.12). Astigmatism was mild in 22.7%, moderate astigmatism in 18.3% in KCN and suspect KCN.CONCLUSION: Increase KCN condition in healthy siblings of KCN patients shows require of screening to early diagnose and cautious treatment of contact lens in these individuals.
ABSTRACT
AIM: To evaluate Orbscan II corneal topography in hyperopic cases.METHODS: A retrospective, observational, consecutive, clinical case series in two hundred and ninety five eyes of hyperopic patients who undergo a LASIK evaluation. The information that was reviewed included age and sex of the patients and the Orbscan II corneal topographic maps. Refractive powers and the following test indices produced by Orbscan II were analyzed: keratometry, corneal diameter, pupil diameter and anterior chamber depth. RESULTS: The total mean corneal thickness was 546.3±35.5μm.It was found ; 547.3±38.4μm in 17-29 years old, 553.4±38.3μm in 30-44 years old and 546.2±29.3μm in older than 45 years old .The mean corneal thickness was found 551.5±35.9μm in female, and 542.6±34.7μm in male. The total mean depth of anterior chamber was 2.57±0.40mm and in 17-29 years old patients was 2.82±0.39mm. In 30-44 years old patients was 2.49±0.39mm and in patients older than 45 years old was 2.37±0.40mm. The mean depth of anterior chamber was 2.53±0.40mm in female and 2.60±0.40mm in male. A reverse significant relation between corneal thickness and keratometry were found. Refractive error severity had a reverse correlation with depth of anterior chamber and a correlation with keratometry (P=0.061,r=0.108).Corneal thickness had a reverse correlation with keratometry (P=0.005,r=0.160), and correlation with pupil diameter (P=0.013, r=0.144).CONCLUSION: This study provides a description and analysis of Orbscan II findings in hyperopic patients. These show mean corneal thickness 546.3±35.5μm and anterior chamber depth 2.57±0.40mm in hyperopic patients.
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AIM:To compare the efficacy of intravitreal triamcino-lone acetonide and conventional treatment for macular edema in retinal vein occlusion.METHODS:In this clinical study 21 patients were enrolled with macular edema due to retinal vein occlu-sion. Prior to treatment, all patients underwent an exten-sive ophthalmic examination. Patients were divided randomly into two groups. Nine patients were treated with 4mg intravitreal triamcinolone acetonide (Kenalog) and 12 patients underwent conventional treatment.RESULTS: Before treatment, logMAR (logarithm minimum angle resolution) visual acuity in conventional treatment was 1.20±0.38 and in Kenalog group it was 1.64±0.31. One month after treatment, the visual acuity was improved to 0.98±0.54 in conventional treatment group and 0.87±0.61 in Kenalog group. There was a significant difference in visual acuity improvement between conventional treatment group and Kenalog group (0.22 vs 0.76) (P=0.01).CONCLUSION:Our results showed that although visual acuity improvement was seen in both groups but Kenalog was more effective than conventional treatment in macular edema due to retinal vein occlusion.